Alzheimer Genetic Risk Scores Do Not Explain SuperAging
A new study demonstrates that SuperAgers cannot be distinguished from cognitively average peers by APOE status or polygenic risk scores.
Current reporting, research and professional developments across Neuropsychology, curated for psychologists and behavioral-health professionals.
A new study demonstrates that SuperAgers cannot be distinguished from cognitively average peers by APOE status or polygenic risk scores.
Increasing mechanical strain causes particle interactions to erase prior directional memory, providing a physical model for how short- and long-term biological memories compete and overwrite.
Keeping the brain healthy is often linked with exercise, a balanced diet, and staying mentally active. However, scientists now believe that financial security may also play an important role. A new ...
A new study demonstrates the feasibility of recall-by-genotype research using the diverse BioMe biobank.
Retirement is simple and appealing: work hard for decades, then stop. But research suggests that when work stops, something in the brain slips. The headline, that working longer tracks with better ...
Even mild inflammation during pregnancy led mouse offspring to develop persistent brain overactivity, sensory sensitivity, repetitive behaviors, and increased seizure risk. Remarkably, one dose of rapamycin improved…
Scientists expected SuperAgers might simply inherit fewer Alzheimer’s-related risks, but their genes looked much like those of typical older adults. Their extraordinary memories may instead come from still-unknown…
Newer oral drugs related to semaglutide medications such as Ozempic reduced pleasure-driven eating in mice by quieting a deep brain reward circuit. The finding could open new avenues for understanding food cravings and…
For most people, dementia sits in the same category as a lightning strike: terrifying, random, out of your hands. The largest review says otherwise: in its 2024 update, the Lancet Commission concluded ...
Frailty is often thought of as a normal part of growing older, but new research suggests it may have a much bigger impact on brain health than previously believed. Scientists have found that older ...
Researchers from the Vrije Universiteit Brussel (VUB) are playing a key role in the summer exhibition wONDERLAND at the Yper Museum. Thanks to interdisciplinary research on more than 1,000 excavated skeletons, they have…
(Brasil2/Canva) If you click on the TV and hear a voice from your childhood saying, "That idiot box is going to rot your brain!" – you're not alone. My grandma said exactly that whenever she walked by ...
There are 982,000 people living with dementia in the UK, according to Alzheimer’s Research UK, and this is expected to rise to 1.4 million by 2040. Avoiding cognitive decline is a priority for many of ...
Museums, libraries, archives and heritage organizations face a difficult problem: Many of the objects they preserve are made from materials that naturally deteriorate.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder lacking effective disease-modifying therapies. A promising regenerative approach involves enhancing endogenous neurogenic capacity within the injured…
Factors influencing pupil size can be experimentally controlled or held constant in laboratory experiments, but how the pupil reflects changes in retinal input from the visual environment in real-world viewing conditions…
Parkinsonism comprises a group of progressive neurodegenerative disorders, including Parkinson’s disease and atypical parkinsonism. In advanced stages, advance care planning (ACP) and coordinated care are important to…
Maternal consumption of hyperpalatable cafeteria diets has been associated with adverse outcomes in offspring. This exploratory pilot study evaluated potential metabolic, growth trajectory, histological, neurochemical…
Attentional focus instructions have long been recognized for their impact on motor performance and learning, yet their influence on the neuromechanical aspects of gait—spanning multiple analytical levels—remains…
Locomotion - whether walking, running, or crawling - depends on the precise coordination of forces between the body and its surroundings. Two critical factors in this process are the force that resists the relative…
Working memory and evidence integration are fundamental components of cognition. Theoretical and behavioral studies argue that both processes are required for plume navigation, a behavior in which animals use stochastic…
Correction to: Communications Biology https://doi.org/10.1038/s42003-025-09088-3, published online 06 November 2025 Following publication of this article, the title has been updated to clarify that the study was…
To investigate how ischemic stroke alters neural activity in the caudal forelimb area (CFA) and identify electrophysiological mechanisms underlying post-stroke motor deficits. Local field potentials were recorded…
Nociceptors, primary afferent nerve fibers that signal noxious stimuli, are broadly divided into slowly conducting unmyelinated C fibers and fast-conducting myelinated A fibers. Whereas C-nociceptors have been…
Sepsis is a deadly syndrome arising from overactivation of the immune system in response to a pathogen. Severe sepsis can result in sepsis-associated encephalopathy (SAE) that significantly contributes to morbidity and…
Radiation-induced brain injury (RBI) is frequently associated with bloodâbrain barrier (BBB) disruption, which contributes to poor prognosis. Neural stem cell-derived exosomes (NSC-Exo) have recently attracted…
Retinal dystrophies such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of individuals worldwide and remain leading causes of irreversible blindness. Photoreceptor transplantation…
Domestic pigs (Sus scrofa domesticus) have been an important animal model for preclinical studies of gene-based therapies related to the treatment of human genetic sensorineural hearing loss, due to their genetic and…
The rapid growth of sustainable finance in recent years has fueled interest in green investment, ranging from green bonds and environmental, social and governance (ESG) funds to energy-efficient cryptocurrencies. While…
A new study reveals that detailed personalized feedback from humanoid robots causes immediate cognitive overload after errors, slowing immediate recovery despite improving long-term task performance.
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