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Na+,K+-ATPases establish and maintain the vital electrochemical gradients for Na+ and K+ across animal cell membranes. The protein is a ternary complex composed of α, β and FXYD subunits, of which isoforms that fine-tune…
Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could…
Traditional models of brain connectivity primarily focus on pairwise interactions, overlooking collective dynamics among multiple regions. Although many higher-order interaction (HOI) metrics have been proposed, their…
Dysfunctional mitophagy is proposed as a key component of Alzheimerâs disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a…
The entorhinal–hippocampal circuit plays a central role in episodic memory, yet the contribution of the medial entorhinal cortex (MEC) ultraslow (< 0.01 Hz) oscillation remains poorly understood. Here, we develop a…
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes…
Hearing loss is a major modifiable risk factor for Alzheimerâs disease (AD), but how auditory deprivation engages specific neural circuits, particularly in a sex-dependent manner, to promote amyloid pathology remains…
Microglia, the brainâs resident immune cells, are increasingly recognized as key regulators of brain physiology and behavior. However, their specific role in affective states remains controversial, with studies…
Low-dimensional manifolds underlie mental and cognitive representations, and characterizing individual differences is critical to neuropsychiatric research. Existing manifold learning methods either distort…
Memory formation relies on the reorganization of neural activity patterns during experience that persist in subsequent sleep. How these processes promote learning while preserving established memories remains unclear…
Several modifiable risk factors for dementias have been identified including socio-economic status and environmental exposures â however, how these population-level risks relate to individual risk remains elusive. To…
Persistent dizziness is a frequent and disabling symptom after retrosigmoid microsurgery for vestibular schwannoma (VS), negatively affecting quality of life. While vestibular outcomes are well studied, the contribution…
Understanding how scientific research informs policy is central to the social sciences, yet systematic evidence of this process remains limited. Bearing in mind that uses can take many different forms, we present a…
Neuroimaging studies using a variety of techniques have demonstrated abnormal patterns of spontaneous brain activity in patients with late-life depression (LLD). However, the findings are variable and often inconsistent…
Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight…
Shift work is associated with an increased risk of sleep disorders, yet tailored prevention and treatment programs remain rare and understudied. Cognitive behavioral therapy for insomnia is the first-line treatment for…
The growing integration of digital technologies into healthcare requires understanding the impact of different consultation modalities on patient stress, memory and perceived credibility. This study compared different…
Health-related quality of life (HRQoL) among breast cancer survivors varies widely from diagnosis through post-treatment; however, distinct recovery patterns remain underexplored. In this study, we used a person-centered…
Guided by social cognitive theory, this study explored the direct and serial chain-mediating relationships between peer assessment quality (PAQ) and English writing ability (EWA), with learning engagement (LE) and…
Street vegetation can play an important multifunctional role in increasing green spaces for more just, healthy and sustainable cities. However, there is still limited knowledge on how greenery exposure and seasonal…
Altercentric and egocentric biases (AB, EB) refer to the impact of another agentâs/own perspective on the speed with which one can report oneâs own/another visual perspective respectively. These biases are known to…
Although the link between depression and social media addiction in adolescents is well established, the specific mechanisms driving this association remain underexplored. This study aims to investigate how physical…
Insomnia symptoms are common and have been associated with disrupted circadian rhythms, altered eating behaviors, and poorer diet quality. Cognitive Behavioral Therapy for Insomnia (CBTi) is recommended as a first-line…
Adolescent major depressive disorder (MDD) is prevalent yet under-recognized, underscoring the need for scalable and objective assessment tools. We developed and validated smartphone-based speech models for detecting MDD…
Limited access to nature in densely urbanized environments together with technostress are recognized as significant mental health burdens in students. However, how draining environments influence mental health under high…
This study advances understanding of AI-enhanced online teacher education by investigating novel psychological and social mechanisms linking instructor technology integration competence in AI-supported online learning…
In response to the growing need for effective and engaging stroke rehabilitation, this study examined how different goal-setting strategies influence self-efficacy and task performance during upper-limb motor learning…
The Conservation of Resources (COR) theory proposes that different types of resources tend to accumulate and reinforce each other, forming a “caravan of resources.” This study aimed to better understand how social…
Existing self-report mentalizing instruments are beset by replication failures in factor structure, conceptual heterogeneity, and near-universal omission of embodied mentalizing. This research developed and validated the…
The debate about the possible future creation of superhuman artificial agents is characterized by an extreme contrast of positions: Some thinkers expect that such agents will enable us to overcome poverty, disease, and…
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