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Researchers are increasingly studying cognitive and psychological constructs using automated online tools due to advantages in scalability, repeatability, accessibility and affordability. The online assessment of sleep…
Fo Mentality is a culturally embedded psychological orientation rooted in the Chinese sociocultural context and prevalent among contemporary young adults. Although labeled with the term “Fo” (Buddha), the construct…
BackgroundPhysical activity is consistently associated with reduced anxiety in adolescents, yet the psychological mechanisms underlying this association remain unclear. This study examined whether resilience and…
ObjectiveThis study examined the association between integrated physical education course experience and exercise adherence tendency among undergraduates in Sichuan Province, China. It focused on indirect associations…
This retrospective study quantified between-class variation in university students' physical fitness and examined individual- and class-level correlates, using annual surveillance records collected from 2020 to 2024 at…
ObjectiveUnderstanding low-carbon behavior remains a significant challenge due to the complexity of environmental decision-making and the persistent intention–behavior gap. While the Theory of Planned Behavior (TPB) and…
To explore the chain mediating effect of perspective taking and general trust between social value orientation and college students’ aggressive behavior, and to provide scientific evidence for promoting college students’…
IntroductionMothers and caregivers of children with intellectual and developmental disabilities often experience depression, anxiety, parenting stress, emotional exhaustion, and reduced psychological wellbeing because of…
Lipocalin-2 (LCN2) has been implicated in the pathogenesis of sepsis-associated encephalopathy (SAE). Our previous work demonstrated a significant increase in astrocyte-derived LCN2 in the hippocampal region during SAE…
Nucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a critical…
Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we…
Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock…
With growing knowledge of the neural circuitry involved in alcohol use disorder (AUD), interest in developing neural-circuit-based therapeutic tools, including transcranial magnetic stimulation (TMS), for people with AUD…
Before hearing onset, inner hair cells in altricial mammals show spontaneous electrical activity crucial for proper auditory pathway development. This activity is finely regulated by descending efferent nerves from the…
To establish a rat model of cerebral ischemiaâreperfusion injury (CIRI) to investigate how chloride intracellular channel protein 1 (CLIC1) exacerbates neuronal damage and to assess the neuroprotective effect of its…
Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy)…
Neuroinflammation is responsible for many neurodegenerative diseases and conditions. In this study, neuroprotective effect of resveratrol was aimed to be investigated in lipopolysaccharide (LPS)-induced neuroinflammatory…
Intraventricular hemorrhage (IVH), the most common, severe neurological complication of preterm birth, causes post-hemorrhagic hydrocephalus (PHH) in up to 30% of cases, which is associated with substantial morbidity…
Sleep deprivation substantially impairs driving performance, underscoring the need for Electroencephalography (EEG)-derived markers associated with driving-performance vulnerability under varying levels of sleepiness. In…
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists…
As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my motherâs APOE genotype with her showed me how…
In Alzheimer’s disease (AD), the role of Actin-binding LIM protein 1 (ABLIM1), which is highly enriched in the brain endothelium, in blood-brain barrier (BBB) dysfunction remains unclear. Our integrative multi-omics…
Peroxiredoxin 3 (PRDX3) encodes a mitochondrially localized antioxidant enzyme. Biallelic pathogenic variants in PRDX3 cause autosomal recessive spinocerebellar ataxia type 32 (SCAR32), a rare form of spinocerebellar…
γ-aminobutyric acid Type-A (GABAA) αβδ receptors regulate neuronal excitability and contribute to sleep, mood and motor coordination. However, the molecular arrangements of these receptors and the basis of GABA…
Sodium fluoride (NaF) is a ubiquitous environmental pollutant that is widespread and has detrimental impacts on ecosystems and health. Developmentally, fluoride exposure enhances oxidative stress, including neurotoxicity…
Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to…
Both the immune system and gut microbiome play important roles in the physiological response to stress, yet their interplay under conditions of long-term continuous stress remains poorly understood due to the lack of…
Tamoxifen is widely used clinically as an anticancer therapy and is also commonly employed in transgenic mouse models to induce Cre-dependent recombination. Although its toxicity has been documented across multiple cell…
Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence…
The human capacity to construct and share subjective experiences from diverse sensory inputs is central to human cognition, and is vividly exemplified through music listening. Direct, focused music perception has been…
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