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Integrating different sources of information is essential to successful spatial navigation. For instance, animals often rely on a combination of visual impressions, self-motion, olfaction, and other signals to navigate…
Neuronal senescence, triggered by oxidative stress and inflammatory responses, is a significant risk factor for brain aging, ultimately leading to cognitive decline. Apelin-13, an exercise-induced myokine, exhibits…
Accumulating evidence indicates that gut microbiota plays a role in the progression of Parkinson’s disease (PD). Microbiota-based treatments for prodromal PD, which is accompanied by a wide range of neuropsychiatric…
Traumatic brain injury (TBI) elicits robust neuroinflammation and oxidative stress, coupled with an acute inhibition of macro-autophagy (autophagy) in neurons and microglia. Rubicon (Rubcn), a Beclin1 interacting protein…
The platelet to highdensity lipoprotein cholesterol ratio (PHR) is an emerging indicator reflecting the balance between thrombogenesis and lipid metabolism inflammation. This study aimed to investigate the relationship…
Hereditary defects in the function of the inwardly rectifying potassium channel Kir7.1 in the retinal pigment epithelium are associated with the ocular diseases retinitis pigmentosa, Leber congenital amaurosis, and…
The workings of the brain are often compared to those of a computer. Some researchers are testing this analogy to its limits, attempting to build computers containing laboratory-grown cultures of brain cells. In doing…
End-stage renal disease (ESRD) patients exhibit a high prevalence of multidimensional frailty, yet its neurobiological correlates remain unclear. This study investigated neuroimaging correlates of frailty in ESRD and…
Sleep deprivation can be dangerous, but it’s difficult to measure.Credit: Getty How does the brain know when it’s time to wake up? Researchers have identified1 a chemical signal that serves as a timer in the mouse brain…
Two scientists blend their love of music and science in different ways. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our…
This study investigates how heterogeneity in lifestyle and physical fitness shapes patterns of brain ageing in depression. The study sample included medically healthy adults from the UK Biobank (44–82 years) with a…
Habits are essential for sustaining adaptive behaviors but can also lead to maladaptive behaviors such as compulsive and addictive disorders. They emerge through a shift in decision-making from motivation-driven strategy…
Calcium imaging is a central method in neuroscience but it records neuronal activity only indirectly and thereby produces results that are difficult to interpret. Here we evaluate the GCaMP8 calcium indicator variants…
The brainâs capacity for information processing depends on precisely regulated energy dynamics. Yet how metabolic supply adapts to shifting computational demands across brain states remains unclear. Using wide-field…
Spontaneous subarachnoid hemorrhage (SAH) remains a life-threatening type of hemorrhagic stroke. Astrocytes are key cellular responders after SAH. We designed the current study to elucidate the global astrocyte reaction…
Post-mortem tau pathology is frequently observed in Parkinsonâs disease (PD) using immunohistochemistry (IHC) to measure large inclusions. However, small protein aggregates that precede inclusions are considered a…
Correction to: Molecular Psychiatry https://doi.org/10.1038/s41380-026-03560-0; published online 02 April 2026 Following publication of this article, the authors identified an error in the corresponding authorship…
Voltage-gated sodium channels regulate neuronal excitability and synaptic transmission in the postnatal and adult brain. The gene SCN2A, encoding the sodium channel Nav1.2, regulates synaptic development and variants in…
Brain health is central to Africaâs development, but current financing and policy frameworks remain poorly matched to the scale and distribution of need. Upstream economic risks, such as poverty, inequality, food…
In order to improve their performance, musicians devote thousands of hours to practising their instrument. However, how practise shapes the behaviour of muscles involved in music-making is not yet fully understood. Using…
Emotion dysregulation (ED) is a core transdiagnostic feature of several psychiatric disorders, including borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These ED disorders…
What makes some people willing to help strangers at a personal cost, while others are more hesitant or selective? Early life adversity - such as neglect or abuse - may shape how we respond to strangers in need later in…
Social anxiety (SA) frequently co-occurs with autism spectrum disorder (ASD), but it remains unclear whether SA in ASD reflects greater symptom severity or a distinct subtype. Across two complementary studies, we…
Force of Nature: Understanding Evolution’s Deepest Logic — and Putting It to Use Owen D. Jones W. W. Norton (2026) From antimicrobial resistance and vaccines to drugs design and even policymaking, evolution is…
Physically and visually disabled persons in nursing-home based care face numerous challenges and are a vulnerable population subjected to environmental barriers and restrictions potentially leading to poor quality of…
Historically, personality traits have been viewed as highly stable and âset like plasterâ once people reach adulthood. Although decades of research have refuted this claim, it remains unclear how much personality…
The interplay between sleep, light exposure, and circadian rhythms is critical for health, yet it remains inadequately described in the everyday lives of parents with young infants. Prior work has focused mainly on…
Radical climate protests have been theorized to shape perceptions of moderate climate groups, a dynamic known as the radical flank effect (RFE). We examine this phenomenon through a longitudinal analysis of German media…
As humanoid robots and artificial intelligence technologies advance, people’s concerns about non-human entities becoming like or replacing humans are increasing. However, considering the prospect of coexistence with…
Children and youth face rising mental health challenges in an increasingly digital world. Universal Tier 1 digital mental health interventions (DMHIs)—low-intensity, high-reach supports for non-clinical populations—have…
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